radiosynthesis and quality control of [67ga]-3,4-dimethoxylated porphyrin complex as a possible imaging agent
نویسندگان
چکیده
radiolabeled porphyrins are potential tumor avid radiopharmaceuticals because of their impersonation in the human body, ability to complex various radionuclides, water solubility, low toxicity etc. in this work a radiogallium porphyrin complex has been developed. [67ga] labeled 5,10,15,20-tetrakis(3,4-dimethoxyphenyl) porphyrin ([67ga]-tdmpp) was prepared using freshly prepared [67ga]gacl3 and 5,10,15,20-tetrakis(3,4-dimethoxyphenyl) porphyrin (h2tdmpp) for 60 min at 100c (. stability of the complex was checked in final formulation and human serum for 24 h, followed by biodistribution and imaging studies in wild type rats up to 24 h. the radiocomplex was obtained with radiochemical purity >99% (itlc) and >98% (hplc), specific activity: 12-15 gbq/mmol. the partition coefficient was determined (log p=1.63). a detailed comparative pharmacokinetic study performed for 67ga cation and [67ga]-tdmpp. the complex is mostly washed out from the circulation through kidneys. myocardial uptake was significantly observed by spect and biodistribution studies. knee and shoulder joints demonstrated significant activity uptake in 2h post injection. higher water solubility of the complex due to ionic nature of the complex is an advantage for rapid wash-out of the complex from the system, the complex has significant joint uptake compared to other radiolabeled porphyrins which the mechanisms are explained.
منابع مشابه
Radiosynthesis and Quality Control of [67Ga]-3,4-dimethoxylated Porphyrin Complex as a Possible Imaging agent
Radiolabeled porphyrins are potential tumor avid radiopharmaceuticals because of their impersonation in the human body, ability to complex various radionuclides, water solubility, low toxicity etc. in this work a radiogallium porphyrin complex has been developed. [67Ga] labeled 5,10,15,20-tetrakis(3,4-dimethoxyphenyl) porphyrin ([67Ga]-TDMPP) was prepared using freshly prepared [67Ga]GaCl3 and ...
متن کاملRadiosynthesis and Quality Control of [67Ga]-3,4-dimethoxylated Porphyrin Complex as a Possible Imaging agent
Radiolabeled porphyrins are potential tumor avid radiopharmaceuticals because of their impersonation in the human body, ability to complex various radionuclides, water solubility, low toxicity etc. in this work a radiogallium porphyrin complex has been developed. [67Ga] labeled 5,10,15,20-tetrakis(3,4-dimethoxyphenyl) porphyrin ([67Ga]-TDMPP) was prepared using freshly prepared [67Ga]GaCl3 and ...
متن کاملRadiosynthesis and Quality Control of [67Ga]-3,4-dimethoxylated Porphyrin Complex as a Possible Imaging agent
Radiolabeled porphyrins are potential tumor avid radiopharmaceuticals because of their impersonation in the human body, ability to complex various radionuclides, water solubility, low toxicity etc. In this work a radiogallium porphyrin complex has been developed. [(67)Ga] labeled 5,10,15,20-tetrakis(3,4-dimethoxyphenyl) porphyrin ([(67)Ga]-TDMPP) was prepared using freshly prepared [(67)Ga]GaCl...
متن کاملRadiosynthesis and biological evaluation of 111In-tris [8-Hydroxy-2-methylquinoline] complex as a possible imaging agent
Introduction: Due to the interesting pharmacological properties of radiolabeled metal oxine derivatives such as cell internalization, tumor avidity and antiproteosome activity, 111In-tris[8-Hydroxy-2-methylquinoline] (111In-HMQ) was developed in this study. Methods: 111In-HMQ was prepared using 111InCl3 and 8-Hydroxy-2-methylquinoline (HMQ) ...
متن کاملPreparation of a 153Sm-5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin complex as a possible therapeutic agent
Introduction: Porphyrins are interesting derivatives with low toxicity, tumor avidity and rapid wash-out suggested as potential radiopharmaceuticals in radiolabeled form. In this work we report, synthesis, radiolabeling, quality control, stability, partition coefficient determination and biodistribution studies of 153Sm-5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin (153Sm-4-MPP) in ...
متن کاملradiosynthesis and biological evaluation of 111in-tris [8-hydroxy-2-methylquinoline] complex as a possible imaging agent
introduction: due to the interesting pharmacological properties of radiolabeled metal oxine derivatives such as cell internalization, tumor avidity and antiproteosome activity, 111in-tris[8-hydroxy-2-methylquinoline] (111in-hmq) was developed in this study. methods: 111in-hmq was prepared using 111incl3 and 8-hydroxy-2-methylquinoline (hmq) for 60 min at 100°c (radiochemical purity: >99% itlc, ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of pharmaceutical researchجلد ۱۲، شماره ۴، صفحات ۷۳۵-۷۴۴
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023